Simulating and Conducting Phase 123 Trials

Documentation for package ‘Phase123’ version 2.1

AssignEffTox	Determines the optimal dose to assign the next patient cohort.
EFFTOX	Obtains estimated posterior probabilities of the four outcomes of (YE,YT) for each dose.
PieceMCMC	Returns posterior distribution for key mixture model parameters
RandomEffTox	Randomizes Eff-Tox dose proportional to posterior desireability scores.
Reoptimize	Gives the Optimal Dose for enrolling next patient cohort.
Reoptimize1	Gives the Optimal Dose for enrolling next patient cohort. Used in the SimPhase123 function.
ReturnMeanControl	Gives true mean survival times for the control therapy.
ReturnMeansAgent	Gives true mean survival times for doses considered of the experimental agent.
ReturnOCS	Gives operating characteristics of phase 123 and conventional design.
RunAdaptiveEffToxTrial	Simulates repitions of an Adaptive Eff-Tox Trial.
SimPhase123	Simulates replications of the phase123 and phase 12-3 trials.
SimPhase3	Performs one replication of phase 3 for the phase 123 design, given phase 12 data.