Clinical Trial Simulation

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Documentation for package ‘simtrial’ version 0.4.2

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

as_gt	Convert summary table to a gt object
as_gt.simtrial_gs_wlr	Convert summary table to a gt object
counting_process	Process survival data into counting process format
create_cut	Create a cutting function
create_test	Create a cutting test function
cut_data_by_date	Cut a dataset for analysis at a specified date
cut_data_by_event	Cut a dataset for analysis at a specified event count
early_zero	Zero early weighting function
ex1_delayed_effect	Time-to-event data example 1 for non-proportional hazards working group
ex2_delayed_effect	Time-to-event data example 2 for non-proportional hazards working group
ex3_cure_with_ph	Time-to-event data example 3 for non-proportional hazards working group
ex4_belly	Time-to-event data example 4 for non-proportional hazards working group
ex5_widening	Time-to-event data example 5 for non-proportional hazards working group
ex6_crossing	Time-to-event data example 6 for non-proportional hazards working group
fh	Fleming-Harrington weighting function
fit_pwexp	Piecewise exponential survival estimation
get_analysis_date	Derive analysis date for interim/final analysis given multiple conditions
get_cut_date_by_event	Get date at which an event count is reached
maxcombo	MaxCombo test
mb	Magirr and Burman weighting function
mb_delayed_effect	Simulated survival dataset with delayed treatment effect
milestone	Milestone test for two survival curves
multitest	Perform multiple tests on trial data cutting
randomize_by_fixed_block	Permuted fixed block randomization
rmst	RMST difference of 2 arms
rpwexp	The piecewise exponential distribution
rpwexp_enroll	Generate piecewise exponential enrollment
sim_fixed_n	Simulation of fixed sample size design for time-to-event endpoint
sim_gs_n	Simulate group sequential designs with fixed sample size
sim_pw_surv	Simulate a stratified time-to-event outcome randomized trial
summary.simtrial_gs_wlr	Summary of group sequential simulations.
to_sim_pw_surv	Convert enrollment and failure rates from 'sim_fixed_n()' to 'sim_pw_surv()' format
wlr	Weighted logrank test
wlr.counting_process	Weighted logrank test
wlr.tte_data	Weighted logrank test